Features of the Circulation of ARVI Pathogens During of Emergence and Widespread of SARS-CoV-2 in the 2018–2021

Relevance. The long-term leadership of ARVI pathogens determines their significance in the damage caused to both health and economy country. Aim. To identify features structure during emergence widespread spread SARS-CoV-2. Materials methods. article uses methods used epidemiological surveillance acute respiratory viral infections. Results discussion. results diagnostic available monitoring epidemic seasons 2018-2021 are presented. tendency greater engagement aged group 15 y.o. older process by morbidity hospitalization due SARI was shown. 49 818 nasal swabs from patients with influenza infection, 36 044 – 59 062 SARS-CoV-2 were tested. top three INF, HEV-D HRSV (in 2018–2019 season); (2019–2020); SARS-CoV-2, HPIV/HCoV (2020–2021). activity also differed: for HPIV, HAdV, HEV-D, HMPV, a decrease noted appearance (2019–2020) some its growth following season; relation INF - last two seasons, extremely low 2020-2021 seasonal HCoV even increased slightly. data genetic analyses positive samples showed heterogeneity population representative variants (Alfa, Delta) as well endemic Russia Moscow only. recommended composition virus vaccines use 2021–2022 northern hemisphere season 2022 southern presented drift changeability. Conclusions. influenced almost complete displacement viruses circulation period 2020–2021.